diff --git a/contrib/boost-cmake/CMakeLists.txt b/contrib/boost-cmake/CMakeLists.txt
index 7191393533b..cc070ec72bd 100644
--- a/contrib/boost-cmake/CMakeLists.txt
+++ b/contrib/boost-cmake/CMakeLists.txt
@@ -69,6 +69,11 @@ set (SRCS_PROGRAM_OPTIONS
     "${LIBRARY_DIR}/libs/program_options/src/winmain.cpp"
 )
 
+# Always compile this file with the highest possible level of optimizations, even in Debug builds.
+# Otherwise the client takes too long to start and SQL stateless tests (many options to parse)
+# https://github.com/ClickHouse/ClickHouse/issues/65745
+set_source_files_properties(${SRCS_PROGRAM_OPTIONS} PROPERTIES COMPILE_FLAGS "-O3")
+
 add_library (_boost_program_options ${SRCS_PROGRAM_OPTIONS})
 add_library (boost::program_options ALIAS _boost_program_options)
 target_include_directories (_boost_program_options SYSTEM BEFORE PUBLIC ${LIBRARY_DIR})
diff --git a/contrib/jemalloc-cmake/CMakeLists.txt b/contrib/jemalloc-cmake/CMakeLists.txt
index 191886981c3..9ebd64db81a 100644
--- a/contrib/jemalloc-cmake/CMakeLists.txt
+++ b/contrib/jemalloc-cmake/CMakeLists.txt
@@ -164,14 +164,16 @@ target_compile_definitions(_jemalloc PRIVATE -DJEMALLOC_NO_PRIVATE_NAMESPACE)
 # Because our coverage callbacks call malloc, and recursive call of malloc could not work.
 target_compile_options(_jemalloc PRIVATE ${WITHOUT_COVERAGE_FLAGS_LIST})
 
-if (CMAKE_BUILD_TYPE_UC STREQUAL "DEBUG")
-    target_compile_definitions(_jemalloc PRIVATE
-        -DJEMALLOC_DEBUG=1
-        # Usage examples:
-        # - MALLOC_CONF=log:.
-        # - MALLOC_CONF='log:core.malloc.exit|core.sallocx.entry|core.sdallocx.entry'
-        -DJEMALLOC_LOG=1)
-endif ()
+# We don't enable Jemalloc DEBUG and log anymore since those have a big impact in performance, specially noticeable
+# when starting the process (really common in stateless tests with the client)
+#if (CMAKE_BUILD_TYPE_UC STREQUAL "DEBUG")
+#    target_compile_definitions(_jemalloc PRIVATE
+#        -DJEMALLOC_DEBUG=1
+#        # Usage examples:
+#        # - MALLOC_CONF=log:.
+#        # - MALLOC_CONF='log:core.malloc.exit|core.sallocx.entry|core.sdallocx.entry'
+#        -DJEMALLOC_LOG=1)
+#endif ()
 
 target_compile_definitions(_jemalloc PRIVATE -DJEMALLOC_PROF=1)