diff --git a/CMakeLists.txt b/CMakeLists.txt
index 09b945c9fb3..cc1a64a9e96 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -393,7 +393,11 @@ else()
 endif ()
 
 option (ENABLE_GWP_ASAN "Enable Gwp-Asan" ON)
-if (NOT OS_LINUX AND NOT OS_ANDROID)
+# We use mmap for allocations more heavily in debug builds, 
+# but GWP-ASan also wants to use mmap frequently, 
+# and due to a large number of memory mappings, 
+# it does not work together well.
+if ((NOT OS_LINUX AND NOT OS_ANDROID) OR (CMAKE_BUILD_TYPE_UC STREQUAL "DEBUG"))
     set(ENABLE_GWP_ASAN OFF)
 endif ()