diff --git a/programs/local/LocalServer.cpp b/programs/local/LocalServer.cpp
index 957bda4d75c..5e9b1570b66 100644
--- a/programs/local/LocalServer.cpp
+++ b/programs/local/LocalServer.cpp
@@ -262,6 +262,17 @@ try
     if (mark_cache_size)
         global_context->setMarkCache(mark_cache_size);
 
+    /// Size of cache for uncompressed blocks of MergeTree indices. Zero means disabled.
+    size_t index_uncompressed_cache_size = config().getUInt64("index_uncompressed_cache_size", 0);
+    if (index_uncompressed_cache_size)
+        global_context->setIndexUncompressedCache(index_uncompressed_cache_size);
+
+    /// Size of cache for index marks (index of MergeTree skip indices). It is necessary.
+    /// Specify default value for index_mark_cache_size explicitly!
+    size_t index_mark_cache_size = config().getUInt64("index_mark_cache_size", 0);
+    if (index_mark_cache_size)
+        global_context->setIndexMarkCache(index_mark_cache_size);
+
     /// A cache for mmapped files.
     size_t mmap_cache_size = config().getUInt64("mmap_cache_size", 1000);   /// The choice of default is arbitrary.
     if (mmap_cache_size)
diff --git a/programs/server/Server.cpp b/programs/server/Server.cpp
index 7c1527bf4b0..55283e7cf46 100644
--- a/programs/server/Server.cpp
+++ b/programs/server/Server.cpp
@@ -942,6 +942,17 @@ if (ThreadFuzzer::instance().isEffective())
     }
     global_context->setMarkCache(mark_cache_size);
 
+    /// Size of cache for uncompressed blocks of MergeTree indices. Zero means disabled.
+    size_t index_uncompressed_cache_size = config().getUInt64("index_uncompressed_cache_size", 0);
+    if (index_uncompressed_cache_size)
+        global_context->setIndexUncompressedCache(index_uncompressed_cache_size);
+
+    /// Size of cache for index marks (index of MergeTree skip indices). It is necessary.
+    /// Specify default value for index_mark_cache_size explicitly!
+    size_t index_mark_cache_size = config().getUInt64("index_mark_cache_size", 0);
+    if (index_mark_cache_size)
+        global_context->setIndexMarkCache(index_mark_cache_size);
+
     /// A cache for mmapped files.
     size_t mmap_cache_size = config().getUInt64("mmap_cache_size", 1000);   /// The choice of default is arbitrary.
     if (mmap_cache_size)
diff --git a/src/Interpreters/AsynchronousMetrics.cpp b/src/Interpreters/AsynchronousMetrics.cpp
index fd02aa4abec..19c45257846 100644
--- a/src/Interpreters/AsynchronousMetrics.cpp
+++ b/src/Interpreters/AsynchronousMetrics.cpp
@@ -546,6 +546,22 @@ void AsynchronousMetrics::update(std::chrono::system_clock::time_point update_ti
         }
     }
 
+    {
+        if (auto index_mark_cache = getContext()->getIndexMarkCache())
+        {
+            new_values["IndexMarkCacheBytes"] = index_mark_cache->weight();
+            new_values["IndexMarkCacheFiles"] = index_mark_cache->count();
+        }
+    }
+
+    {
+        if (auto index_uncompressed_cache = getContext()->getIndexUncompressedCache())
+        {
+            new_values["IndexUncompressedCacheBytes"] = index_uncompressed_cache->weight();
+            new_values["IndexUncompressedCacheCells"] = index_uncompressed_cache->count();
+        }
+    }
+
     {
         if (auto mmap_cache = getContext()->getMMappedFileCache())
         {
diff --git a/src/Interpreters/Context.cpp b/src/Interpreters/Context.cpp
index 583f59c20b5..e11d5eb1c14 100644
--- a/src/Interpreters/Context.cpp
+++ b/src/Interpreters/Context.cpp
@@ -184,6 +184,8 @@ struct ContextSharedPart
     std::unique_ptr<AccessControlManager> access_control_manager;
     mutable UncompressedCachePtr uncompressed_cache;        /// The cache of decompressed blocks.
     mutable MarkCachePtr mark_cache;                        /// Cache of marks in compressed files.
+    mutable UncompressedCachePtr index_uncompressed_cache;  /// The cache of decompressed blocks for MergeTree indices.
+    mutable MarkCachePtr index_mark_cache;                  /// Cache of marks in compressed files of MergeTree indices.
     mutable MMappedFileCachePtr mmap_cache; /// Cache of mmapped files to avoid frequent open/map/unmap/close and to reuse from several threads.
     ProcessList process_list;                               /// Executing queries at the moment.
     MergeList merge_list;                                   /// The list of executable merge (for (Replicated)?MergeTree)
@@ -1420,6 +1422,56 @@ void Context::dropMarkCache() const
 }
 
 
+void Context::setIndexUncompressedCache(size_t max_size_in_bytes)
+{
+    auto lock = getLock();
+
+    if (shared->index_uncompressed_cache)
+        throw Exception("Index uncompressed cache has been already created.", ErrorCodes::LOGICAL_ERROR);
+
+    shared->index_uncompressed_cache = std::make_shared<UncompressedCache>(max_size_in_bytes);
+}
+
+
+UncompressedCachePtr Context::getIndexUncompressedCache() const
+{
+    auto lock = getLock();
+    return shared->index_uncompressed_cache;
+}
+
+
+void Context::dropIndexUncompressedCache() const
+{
+    auto lock = getLock();
+    if (shared->index_uncompressed_cache)
+        shared->index_uncompressed_cache->reset();
+}
+
+
+void Context::setIndexMarkCache(size_t cache_size_in_bytes)
+{
+    auto lock = getLock();
+
+    if (shared->index_mark_cache)
+        throw Exception("Index mark cache has been already created.", ErrorCodes::LOGICAL_ERROR);
+
+    shared->index_mark_cache = std::make_shared<MarkCache>(cache_size_in_bytes);
+}
+
+MarkCachePtr Context::getIndexMarkCache() const
+{
+    auto lock = getLock();
+    return shared->index_mark_cache;
+}
+
+void Context::dropIndexMarkCache() const
+{
+    auto lock = getLock();
+    if (shared->index_mark_cache)
+        shared->index_mark_cache->reset();
+}
+
+
 void Context::setMMappedFileCache(size_t cache_size_in_num_entries)
 {
     auto lock = getLock();
@@ -1454,6 +1506,12 @@ void Context::dropCaches() const
     if (shared->mark_cache)
         shared->mark_cache->reset();
 
+    if (shared->index_uncompressed_cache)
+        shared->index_uncompressed_cache->reset();
+
+    if (shared->index_mark_cache)
+        shared->index_mark_cache->reset();
+
     if (shared->mmap_cache)
         shared->mmap_cache->reset();
 }
diff --git a/src/Interpreters/Context.h b/src/Interpreters/Context.h
index 1b636deb532..9928022b841 100644
--- a/src/Interpreters/Context.h
+++ b/src/Interpreters/Context.h
@@ -667,6 +667,16 @@ public:
     std::shared_ptr<MarkCache> getMarkCache() const;
     void dropMarkCache() const;
 
+    /// Create a cache of index uncompressed blocks of specified size. This can be done only once.
+    void setIndexUncompressedCache(size_t max_size_in_bytes);
+    std::shared_ptr<UncompressedCache> getIndexUncompressedCache() const;
+    void dropIndexUncompressedCache() const;
+
+    /// Create a cache of index marks of specified size. This can be done only once.
+    void setIndexMarkCache(size_t cache_size_in_bytes);
+    std::shared_ptr<MarkCache> getIndexMarkCache() const;
+    void dropIndexMarkCache() const;
+
     /// Create a cache of mapped files to avoid frequent open/map/unmap/close and to reuse from several threads.
     void setMMappedFileCache(size_t cache_size_in_num_entries);
     std::shared_ptr<MMappedFileCache> getMMappedFileCache() const;
diff --git a/src/Interpreters/InterpreterSystemQuery.cpp b/src/Interpreters/InterpreterSystemQuery.cpp
index d4ac555add0..03a23e9eb35 100644
--- a/src/Interpreters/InterpreterSystemQuery.cpp
+++ b/src/Interpreters/InterpreterSystemQuery.cpp
@@ -277,6 +277,14 @@ BlockIO InterpreterSystemQuery::execute()
             getContext()->checkAccess(AccessType::SYSTEM_DROP_UNCOMPRESSED_CACHE);
             system_context->dropUncompressedCache();
             break;
+        case Type::DROP_INDEX_MARK_CACHE:
+            getContext()->checkAccess(AccessType::SYSTEM_DROP_MARK_CACHE);
+            system_context->dropIndexMarkCache();
+            break;
+        case Type::DROP_INDEX_UNCOMPRESSED_CACHE:
+            getContext()->checkAccess(AccessType::SYSTEM_DROP_UNCOMPRESSED_CACHE);
+            system_context->dropIndexUncompressedCache();
+            break;
         case Type::DROP_MMAP_CACHE:
             getContext()->checkAccess(AccessType::SYSTEM_DROP_MMAP_CACHE);
             system_context->dropMMappedFileCache();
@@ -721,6 +729,8 @@ AccessRightsElements InterpreterSystemQuery::getRequiredAccessForDDLOnCluster()
         case Type::DROP_COMPILED_EXPRESSION_CACHE: [[fallthrough]];
 #endif
         case Type::DROP_UNCOMPRESSED_CACHE:
+        case Type::DROP_INDEX_MARK_CACHE:
+        case Type::DROP_INDEX_UNCOMPRESSED_CACHE:
         {
             required_access.emplace_back(AccessType::SYSTEM_DROP_CACHE);
             break;
diff --git a/src/Parsers/ASTSystemQuery.cpp b/src/Parsers/ASTSystemQuery.cpp
index 5d01e124b0e..0f52df2f4ae 100644
--- a/src/Parsers/ASTSystemQuery.cpp
+++ b/src/Parsers/ASTSystemQuery.cpp
@@ -30,6 +30,10 @@ const char * ASTSystemQuery::typeToString(Type type)
             return "DROP MARK CACHE";
         case Type::DROP_UNCOMPRESSED_CACHE:
             return "DROP UNCOMPRESSED CACHE";
+        case Type::DROP_INDEX_MARK_CACHE:
+            return "DROP INDEX MARK CACHE";
+        case Type::DROP_INDEX_UNCOMPRESSED_CACHE:
+            return "DROP INDEX UNCOMPRESSED CACHE";
         case Type::DROP_MMAP_CACHE:
             return "DROP MMAP CACHE";
 #if USE_EMBEDDED_COMPILER
diff --git a/src/Parsers/ASTSystemQuery.h b/src/Parsers/ASTSystemQuery.h
index fa7b6ece59a..c88fd4bf7ad 100644
--- a/src/Parsers/ASTSystemQuery.h
+++ b/src/Parsers/ASTSystemQuery.h
@@ -24,6 +24,8 @@ public:
         DROP_DNS_CACHE,
         DROP_MARK_CACHE,
         DROP_UNCOMPRESSED_CACHE,
+        DROP_INDEX_MARK_CACHE,
+        DROP_INDEX_UNCOMPRESSED_CACHE,
         DROP_MMAP_CACHE,
 #if USE_EMBEDDED_COMPILER
         DROP_COMPILED_EXPRESSION_CACHE,
diff --git a/src/Storages/MergeTree/MergeTreeDataSelectExecutor.cpp b/src/Storages/MergeTree/MergeTreeDataSelectExecutor.cpp
index f5c1890154a..b36b64d5651 100644
--- a/src/Storages/MergeTree/MergeTreeDataSelectExecutor.cpp
+++ b/src/Storages/MergeTree/MergeTreeDataSelectExecutor.cpp
@@ -834,6 +834,9 @@ RangesInDataParts MergeTreeDataSelectExecutor::filterPartsByPrimaryKeyAndSkipInd
         if (settings.read_overflow_mode_leaf == OverflowMode::THROW && settings.max_rows_to_read_leaf)
             leaf_limits = SizeLimits(settings.max_rows_to_read_leaf, 0, settings.read_overflow_mode_leaf);
 
+        auto mark_cache = context->getIndexMarkCache();
+        auto uncompressed_cache = context->getIndexUncompressedCache();
+
         auto process_part = [&](size_t part_index)
         {
             auto & part = parts[part_index];
@@ -870,6 +873,8 @@ RangesInDataParts MergeTreeDataSelectExecutor::filterPartsByPrimaryKeyAndSkipInd
                     reader_settings,
                     total_granules,
                     granules_dropped,
+                    mark_cache.get(),
+                    uncompressed_cache.get(),
                     log);
 
                 index_and_condition.total_granules.fetch_add(total_granules, std::memory_order_relaxed);
@@ -1408,6 +1413,8 @@ MarkRanges MergeTreeDataSelectExecutor::filterMarksUsingIndex(
     const MergeTreeReaderSettings & reader_settings,
     size_t & total_granules,
     size_t & granules_dropped,
+    MarkCache * mark_cache,
+    UncompressedCache * uncompressed_cache,
     Poco::Logger * log)
 {
     const std::string & path_prefix = part->getFullRelativePath() + index_helper->getFileName();
@@ -1433,6 +1440,8 @@ MarkRanges MergeTreeDataSelectExecutor::filterMarksUsingIndex(
         index_helper, part,
         index_marks_count,
         ranges,
+        mark_cache,
+        uncompressed_cache,
         reader_settings);
 
     MarkRanges res;
diff --git a/src/Storages/MergeTree/MergeTreeDataSelectExecutor.h b/src/Storages/MergeTree/MergeTreeDataSelectExecutor.h
index 92c4382dc90..b114f498bf0 100644
--- a/src/Storages/MergeTree/MergeTreeDataSelectExecutor.h
+++ b/src/Storages/MergeTree/MergeTreeDataSelectExecutor.h
@@ -90,6 +90,8 @@ private:
         const MergeTreeReaderSettings & reader_settings,
         size_t & total_granules,
         size_t & granules_dropped,
+        MarkCache * mark_cache,
+        UncompressedCache * uncompressed_cache,
         Poco::Logger * log);
 
     struct PartFilterCounters
diff --git a/src/Storages/MergeTree/MergeTreeIndexReader.cpp b/src/Storages/MergeTree/MergeTreeIndexReader.cpp
index 0a0f2511914..fd7358967f3 100644
--- a/src/Storages/MergeTree/MergeTreeIndexReader.cpp
+++ b/src/Storages/MergeTree/MergeTreeIndexReader.cpp
@@ -11,13 +11,15 @@ std::unique_ptr<MergeTreeReaderStream> makeIndexReader(
     MergeTreeData::DataPartPtr part,
     size_t marks_count,
     const MarkRanges & all_mark_ranges,
+    MarkCache * mark_cache,
+    UncompressedCache * uncompressed_cache,
     MergeTreeReaderSettings settings)
 {
     return std::make_unique<MergeTreeReaderStream>(
         part->volume->getDisk(),
         part->getFullRelativePath() + index->getFileName(), extension, marks_count,
         all_mark_ranges,
-        std::move(settings), nullptr, nullptr,
+        std::move(settings), mark_cache, uncompressed_cache,
         part->getFileSizeOrZero(index->getFileName() + extension),
         &part->index_granularity_info,
         ReadBufferFromFileBase::ProfileCallback{}, CLOCK_MONOTONIC_COARSE);
@@ -29,14 +31,27 @@ namespace DB
 {
 
 MergeTreeIndexReader::MergeTreeIndexReader(
-    MergeTreeIndexPtr index_, MergeTreeData::DataPartPtr part_, size_t marks_count_, const MarkRanges & all_mark_ranges_,
+    MergeTreeIndexPtr index_,
+    MergeTreeData::DataPartPtr part_,
+    size_t marks_count_,
+    const MarkRanges & all_mark_ranges_,
+    MarkCache * mark_cache,
+    UncompressedCache * uncompressed_cache,
     MergeTreeReaderSettings settings)
     : index(index_)
 {
     const std::string & path_prefix = part_->getFullRelativePath() + index->getFileName();
     auto index_format = index->getDeserializedFormat(part_->volume->getDisk(), path_prefix);
 
-    stream = makeIndexReader(index_format.extension, index_, part_, marks_count_, all_mark_ranges_, std::move(settings));
+    stream = makeIndexReader(
+        index_format.extension,
+        index_,
+        part_,
+        marks_count_,
+        all_mark_ranges_,
+        mark_cache,
+        uncompressed_cache,
+        std::move(settings));
     version = index_format.version;
 
     stream->seekToStart();
diff --git a/src/Storages/MergeTree/MergeTreeIndexReader.h b/src/Storages/MergeTree/MergeTreeIndexReader.h
index 4facd43c175..799dae154bf 100644
--- a/src/Storages/MergeTree/MergeTreeIndexReader.h
+++ b/src/Storages/MergeTree/MergeTreeIndexReader.h
@@ -16,6 +16,8 @@ public:
         MergeTreeData::DataPartPtr part_,
         size_t marks_count_,
         const MarkRanges & all_mark_ranges_,
+        MarkCache * mark_cache,
+        UncompressedCache * uncompressed_cache,
         MergeTreeReaderSettings settings);
     ~MergeTreeIndexReader();