diff --git a/src/Analyzer/Passes/UniqInjectiveFunctionsEliminationPass.cpp b/src/Analyzer/Passes/UniqInjectiveFunctionsEliminationPass.cpp
index d087fe1c7b9..2360cd3f0c2 100644
--- a/src/Analyzer/Passes/UniqInjectiveFunctionsEliminationPass.cpp
+++ b/src/Analyzer/Passes/UniqInjectiveFunctionsEliminationPass.cpp
@@ -41,9 +41,9 @@ public:
             return;
 
         bool replaced_argument = false;
-        auto & uniq_function_arguments_nodes = function_node->getArguments().getNodes();
+        auto replaced_uniq_function_arguments_nodes = function_node->getArguments().getNodes();
 
-        for (auto & uniq_function_argument_node : uniq_function_arguments_nodes)
+        for (auto & uniq_function_argument_node : replaced_uniq_function_arguments_nodes)
         {
             auto * uniq_function_argument_node_typed = uniq_function_argument_node->as<FunctionNode>();
             if (!uniq_function_argument_node_typed || !uniq_function_argument_node_typed->isOrdinaryFunction())
@@ -67,12 +67,10 @@ public:
         if (!replaced_argument)
             return;
 
-        const auto & function_node_argument_nodes = function_node->getArguments().getNodes();
-
         DataTypes argument_types;
-        argument_types.reserve(function_node_argument_nodes.size());
+        argument_types.reserve(replaced_uniq_function_arguments_nodes.size());
 
-        for (const auto & function_node_argument : function_node_argument_nodes)
+        for (const auto & function_node_argument : replaced_uniq_function_arguments_nodes)
             argument_types.emplace_back(function_node_argument->getResultType());
 
         AggregateFunctionProperties properties;
@@ -83,6 +81,10 @@ public:
             function_node->getAggregateFunction()->getParameters(),
             properties);
 
+        /// uniqCombined returns nullable with nullable arguments so the result type might change which breaks the pass
+        if (!aggregate_function->getResultType()->equals(*function_node->getAggregateFunction()->getResultType()))
+            return;
+
         function_node->resolveAsAggregateFunction(std::move(aggregate_function));
     }
 };
diff --git a/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.reference b/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.reference
new file mode 100644
index 00000000000..e58e9764b39
--- /dev/null
+++ b/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.reference
@@ -0,0 +1,2 @@
+100
+100
diff --git a/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.sql b/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.sql
new file mode 100644
index 00000000000..50d99b851a6
--- /dev/null
+++ b/tests/queries/0_stateless/03169_optimize_injective_functions_inside_uniq_crash.sql
@@ -0,0 +1,21 @@
+SELECT sum(u)
+FROM
+(
+    SELECT
+        intDiv(number, 4096) AS k,
+        uniqCombined(tuple(materialize(toLowCardinality(toNullable(16))))) AS u
+    FROM numbers(4096 * 100)
+    GROUP BY k
+)
+SETTINGS allow_experimental_analyzer = 1, optimize_injective_functions_inside_uniq=0;
+
+SELECT sum(u)
+FROM
+(
+    SELECT
+        intDiv(number, 4096) AS k,
+        uniqCombined(tuple(materialize(toLowCardinality(toNullable(16))))) AS u
+    FROM numbers(4096 * 100)
+    GROUP BY k
+)
+SETTINGS allow_experimental_analyzer = 1, optimize_injective_functions_inside_uniq=1;